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Glaucoma causes symptoms and treatment

The Glaucoma is an eye disease that causes irreversible reduction of vision. It is the consequence of damage to the optic nerve. It is primarily the peripheral vision that is affected (see images below). The sufferer can become blind if he does not receive any treatment. Glaucoma is also the cause of blindness in the world in the least developed countries in the world after cataract (source OPC 2012).

Most often, glaucoma is associated with subsequent elevation of pressure inside the eye (intraocular pressure). Normally, this should not exceed 21 millimeters of mercury (mmHg).

However, it is found that in nearly 1 in 3 people, glaucoma symptoms occur even if the pressure in the eye is normal. A less good blood supply to the optic nerve, caused by atherosclerosis in the vessels that irrigate this nerve, could be involved. Whether the pressure inside the eye is too high or not, the treatment remains the same.

Who is affected?

In Canada, 1% of people over the age of 40 have it. This proportion rises to 5% among people over 70, and 10% over 80. Glaucoma can still occur at any age.

In France, more than one million people would be affected, including 400,000 people who are not treated by ignorance of the disease. The over 40s are mainly concerned, glaucoma can nevertheless occur at any age.

Causes of Glaucoma

It is often not known why glaucoma appears. The heredity is the main risk factor. In addition, certain anatomical features may play a role.

Sometimes glaucoma is associated with a specific problem, such as:
– a sudden trauma to the eye;
– another problem of sight: cataract, pronounced myopia, chronic uveitis ;
– certain diseases: diabetes, hypertension, cardiovascular disorders, and uncontrolled hypothyroidism.

Taking certain medications also increases the risk of glaucoma. This is the case, for example, corticosteroids administered directly in the eyes or orally.

Note. Corticosteroids pumped for asthma or cream or ointment for eczema has no effect on glaucoma.

Why is the pressure rising?

Inside the eye, between the cornea and the iris, is a space called the anterior chamber (after having enlarged it, click on the interactive diagram below). This space is filled with a liquid called aqueous humor . This transparent liquid has several functions: it maintains the intraocular pressure, gives shape to the eyeball and nourishes the cornea and the lens. The aqueous humor is constantly renewed and circulates in the eye.

In most cases of glaucoma, a decrease in the excretion of aqueous humor through its exit route occurs. The excretion of the fluid is either progressively slowed down, which gradually leads to open-angle glaucoma , or is rapidly blocked, resulting in narrow- angle glaucoma .

Since the aqueous humor does not drain normally, the pressure inside the eye increases. The high pressure will cause an excavation of the head of the optic nerve that alters the optical fibers of the retina and destroys them gradually. This results in a peripheral visual field disorder not usually perceived by the patient.

Types of glaucoma

Open angle glaucoma . With 80% to 90% of cases (in Caucasians, Blacks and Hispanics), this type of glaucoma develops slowly without causing symptoms, over a period of time ranging from 10 years to 20 years. The “angle” in question is that formed by the junction between the iris and the cornea. It is called the iridocorneal angle (see the interactive diagram). Usually both eyes are affected. One of the important precursors is the gradual increase in pressure inside the eye. Normally, this should not exceed 21 millimeters of mercury (mmHg). Intraocular pressure is detectable by visual examination .

Closed angle glaucoma . More rare (except in Asians, where it is common), it occurs as a result of a sudden increase in pressure in the eye. This is a medical emergency . It causes extreme eye pain and other noticeable symptoms, such as vision loss and colored halos around lights. Intraocular pressure sometimes rises up to 80 mmHg. Typically, such fits occur in the evening when the lighting is dim and the pupils dilate. If this type of glaucoma is not treated quickly, the person may become blind. If treated in time, the risk of blindness is greatly reduced.

Close-angle glaucoma attacks first and usually only one eye, then the other within 5 years in the absence of adequate control.
Two factors are required for a seizure to occur:
– Anatomical predisposition.
– A dilation of the pupil (the central orifice of the iris, where the light rays pass). It can occur as a result of prolonged darkness, stress, or the use of drugs that dilate the pupil, such as antispasmodics, antihistamines, antidepressants, and nitrates.

Congenital glaucoma. It can occur from birth or take a few months to manifest. Most often, it touches both eyes. Sometimes hereditary, it can represent an isolated problem or be explained by an ocular malformation (usually a congenital cataract) or certain rare diseases. In this case too, there is blockage of the exit of the aqueous humor.

Diagnostic of Glaucoma

Here are the most commonly performed exams.

Tonometry test. This is the first test generally undertaken. The tonometer measures the pressure inside the eye. Two techniques are employed: one directs a jet of pressurized air on the open eye, it is the pulsed air tonometry; or after instillation of anesthetic eyedrops a flattened cone is placed on the cornea, this is the aplanation tonometry. This test is both fast and painless. Normal intraocular pressure is between 8 mmHg and 21 mmHg.

Measuring the thickness of the cornea. It is important to measure the thickness of the cornea since it influences the result obtained in the tonometry test. If the cornea is thick, the pressure is overestimated; if the cornea is thin, the pressure is underestimated.

Observation of the eye. Indications of damage to the optic nerve can be seen with a device that directs light into the eye.

Field of vision test. To assess the extent of the visual field, the person is asked to fix a target in the center of an illuminated sphere, then a bright spot appears at different points in the visual field.

When to consult?

  • Consult urgently when you feel significant pain in the eye and at the same time the vision drops quickly.
  • Consult an ophthalmologist regularly to prevent any eye condition.
  • Consult a doctor for any problem associated with wearing contact lenses.

The symptoms of glaucoma

Open angle glaucoma

  • Without symptoms for 10 years to 20 years.
  • Then, a tangled peripheral view.
  • Sometimes eye pain and headaches.
  • Blindness, at an advanced stage.

Note. Usually both eyes are affected.

Angle closure glaucoma

  • A very strong eye pain.
  • A vision suddenly blurred.
  • The vision of colorful halos around the light sources.
  • The blushing of the eyes.
  • Nausea and vomiting.

Note. A permanent loss of vision can occur in the day following the crisis, hence the importance of getting treatment as quickly as possible. In general, the crisis only reaches one eye.

Congenital glaucoma

  • Big, often watery eyes.
  • An iris with unclear details.
  • Increased sensitivity to light

Note. Symptoms may take a few months after birth to manifest.

People at risk for Glaucoma

  • People with a family history of glaucoma.
  • People aged 60 and over.
  • Black populations are more likely to have open-angle glaucoma. Their risk increases as soon as they are 40 years old.
    Mexican or Asian populations are also at higher risk.
  • People with diabetes or hypothyroidism.
  • People who suffer from hypotension or hypertension, and those who have already had heart problems.
  • People with another eye problem (pronounced myopia, cataracts, chronic uveitis, pseudoexfoliation , etc.).
  • People who have had a serious injury to an eye (a blow directly to the eye, for example).

Risk factors

  • Use of certain medications, especially those containing corticosteroids (for open-angle glaucoma) or those that dilate the pupil (for angle-closure glaucoma).
  • The consumption of coffee and tobacco would increase momentarily, slightly the pressure inside the eye.

Prevention of glaucoma

Basic preventive measures
  • People who have a higher risk of glaucoma (due to age, family history, diabetes, etc.) are well advised to have a complete eye exam each year, from their forties or earlier need. The sooner the rise in intraocular pressure is detected, the more the loss of visual capacity is minimized.
  • Be sure to maintain a healthy weight and normal blood pressure . R esistance insulin , which often accompanies obesity and hypertension, contributes to raising the pressure inside the eye.
  • Finally, always be careful to protect your eyes with goggles during the practice of risky activities (handling chemicals, welding, squash, speed sports, etc.).
Measures to prevent recurrence

General precautions

  • Avoid the use of certain drugs  – especially corticosteroids in the form of eye drops or orally – or take into account their potential risks.
  • Have a diet rich in fruits and vegetables to meet as much as possible the need for vitamins and minerals.
  • Drink small amounts of liquids at a time so that you do not suddenly increase your intraocular pressure.
  • Limiting or avoiding caffeine and tobacco consumption is sometimes beneficial.
  • Doing the exercise regularly can alleviate some symptoms of open-angle glaucoma, but has no effect on the closed angle. It is best to consult a doctor to choose the appropriate exercises. Watch out for vigorous exercise, some yoga postures and head-down exercises that can increase eye pressure.
  • In the sun, protect the eyes from ultraviolet rays by wearing glasses with tinted lenses that filter 100% UV .

Prevent another angle-closure glaucoma attack

  • Stress can trigger an acute attack of angle-closure glaucoma. You have to pay attention to factors that generate stress and try to find solutions.
  • Following an initial angle-closure glaucoma attack, laser therapy will prevent recurrence. This treatment involves making a small hole in the iris with a laser beam to allow the flow of aqueous humor trapped behind the iris. Most of the time, it is advisable to treat the other eye as a preventive measure.

Medical treatments for glaucoma

Unfortunately, there is no cure . Visual acuity lost due to glaucoma cannot be found. The goal of treatment is to prevent or slow down the subsequent damage . To do this, in many cases, it will be a matter of reducing the pressure inside the eye by improving the circulation of the aqueous humor.

The ophthalmologist , the eye care physician, will develop a treatment plan and monitor visual abilities on a regular basis. Possible interventions include eye drops, oral medications, laser treatment and, if necessary, surgery. In many cases, medications should be taken for life.

If the cause of glaucoma is identifiable, it will be important to treat it. In addition, corticosteroids in the eyes are contraindicated in people with glaucoma. It is therefore advisable not to undertake or stop this type of treatment. In some cases, their use cannot be avoided. It is then necessary to obtain a very good follow-up with an ophthalmologist.

For open angle glaucoma

Ophthalmic drops (eye drops)

They reduce the pressure in the eye. Drops are frequently prescribed because they cause fewer side effects than oral medications.

Several types of ophthalmic drops are used. Among the most common are beta-blockers , alpha-adrenergic agents , prostaglandin analogues , carbonic anhydrase inhibitors, and miotics . The majority of these drugs work by both reducing the production of aqueous humor in the eye and increasing its excretion.

The side effects vary from one type of drop to another. These may include, for example, dry mouth, low blood pressure, decreased heart rate, eye irritation, redness around the eyes, or fatigue. It is best to inform your doctor of the side effects that occur, if any.

It is important to follow the dosage carefully. This treatment is very effective, provided it is followed daily and for life .

Oral medications

If drops do not sufficiently reduce intraocular pressure, which is rare, oral medication may be prescribed (eg, carbonic anhydrase inhibitors). However, these medications more often cause undesirable and more pronounced effects than ophthalmic drops.

Laser treatment

This procedure, called trabeculoplasty , is becoming more commonplace. It even happens that it is proposed before the use of ophthalmic drops. It can also be used if the glaucoma worsens despite treatment or if the medication is poorly tolerated.

This laser treatment aims to help the circulation of the aqueous humor in the eye. The procedure is painless and fast: it is performed in one or two 5-minute sessions. A laser beam is directed at the trabeculum (see diagram of internal structures of the eye above). It is not clear why it decreases the pressure.

Even if a laser intervention is practiced, a drug treatment (most often eye drops) must still be followed for life.

Classic surgery

This eye surgery is called trabeculectomy . The intervention aims to create a new escape route from the aqueous humor by removing a small segment of trabecular meshwork. Tube laying is common. The tube directs the aqueous humor into a reservoir behind the eye. About 80% of people who undergo this surgery no longer need eye drops afterwards.

Other types of surgeries are in experimentation . Eventually, they could replace trabeculectomy. However, it will take several more years to determine their effectiveness. Examples include canalostomy, Ex-Press, canaloplasty, gold implant, Glaukos iStent and trabeculotome.

For narrow-angle glaucoma

An emergency treatment is required. Several medications are used to quickly reduce intraocular pressure.

Once the pressure is lowered, the ideal is to open a passageway through the iris, using a laser beam . This procedure is called peripheral iridotomy . This treatment allows the flow of the aqueous humor, in order to avoid recurrences. Anesthetic drops are previously applied to the eye, as well as a corneal lens (removed after treatment). After treatment, anti-inflammatory drops are prescribed and must be applied to the eye for a few days. Other treatments may be needed.

For congenital glaucoma

Only surgery can correct this type of glaucoma. It is practiced from the first weeks of life.

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